URSA - Drugs and Clinicals ChemCensor: leaderboard
Route plausibility on 100 approved drugs and clinical candidates (URSA, Insilico Medicine, 2026): the mean ChemCensor score, from 0 to 5, per reaction step along the best proposed route of each target, averaged over targets. Higher is better.
Metric: Average ChemCensor plausibility score (out of 5) per reaction step along the best route per target, averaged over the 100 URSA-drugs&clinicals-2026 approved drugs and clinical candidates; URSA-minor-1.1.0-U2 configuration with ChemCensor v1.2.0 and the U2 USPTO precedent database; default reasoning effort; higher is better. Source: arxiv.org. Saturation forecast: Around February 2027. 17 models tracked.
Top models
| # | Model | Score | Overall rank |
|---|---|---|---|
| 1 | GPT-5.5 | 2.43 | #49 |
| 2 | Gemini 3.1 Pro (Preview) | 2.42 | #94 |
| 3 | Grok 4.1 | 2.01 | #476 |
| 4 | Claude Opus 4.8 | 1.99 | #56 |
| 5 | Claude Opus 4.7 | 1.97 | #79 |
| 6 | Kimi K2.5 | 1.78 | #256 |
| 7 | Claude Opus 4.5 | 1.71 | #156 |
| 8 | Qwen 3.5 397B A17B | 1.7 | #246 |
| 9 | Claude Opus 4.6 | 1.67 | #102 |
| 10 | Claude Sonnet 4.5 | 1.53 | #250 |
| 11 | GLM-5 | 1.48 | #260 |
| 12 | Claude Sonnet 4.6 | 1.44 | #161 |
| 13 | GPT-5.4 | 1.43 | #123 |
| 14 | GPT-5.2 | 1.33 | #176 |
| 15 | DeepSeek V3.2 | 1.06 | #406 |
No result here: #1 Claude Fable 5.2, #2 Gemini 4 Carbon, #5 Claude Opus 5.5.
Interactive version: theaggregate.ai/benchmark?slug=ursa-drugs-and-clinicals-chemcensor · How It Works · Data refreshed daily, snapshot 2026-11-13.