SC-Arena - Perturbation Prediction: leaderboard
Metric: Knowledge-augmented judge score from 0 to 100 on SC-Arena perturbation prediction (up- and down-regulated genes and the post-perturbation cell for 138 genetic interventions from the Norman and Adamson screens); a GPT-4o-mini judge given the reference answer and curated external knowledge (Cell Ontology, CellMarker, Gene Ontology, UniProt, NCBI and source literature) rates each answer 0 to 5, rescaled to 0 to 100 and averaged over the task's items; cells are written as cell sentences of ranked gene names; higher is better. Source: arxiv.org. Saturation forecast: Estimated already saturated. 11 models tracked.
Top models
| # | Model | Score | Overall rank |
|---|---|---|---|
| 1 | Qwen 3 32B | 37.54 | #424 |
| 2 | Qwen 3 8B | 37.39 | #667 |
| 3 | GPT-4o | 37.24 | #333 |
| 4 | Kimi K2 | 37.1 | #236 |
| 5 | DeepSeek R1 | 36.23 | #245 |
| 6 | Qwen 2.5 32B | 36.23 | #532 |
| 7 | Qwen 3 235B A22B | 35.94 | #304 |
| 8 | Qwen 2.5 14B | 34.78 | #711 |
| 9 | Qwen 3 14B | 32.89 | #524 |
| 10 | Qwen 2.5 7B | 28.84 | #912 |
No result here: #3 Claude Opus 5.5, #5 GPT-6 Astra, #8 Claude Fable 5.1.
Interactive version: theaggregate.ai/benchmark?slug=sc-arena-perturbation-prediction · How It Works · Data refreshed daily, snapshot 2026-10-11.