ProteinGym Hard: leaderboard
Hard ProteinGym subset reported in Anthropic's Claude Opus 4.8 system card.
Metric: Rank correlation (system card). Source: proteingym.org. Source: benchmarklist.com. Saturation forecast: Around October 2027. 10 models tracked.
Top models
| # | Model | Score | Overall rank |
|---|---|---|---|
| 1 | Claude Mythos 5.1 | 49.3 | #1 |
| 2 | Claude Opus 5 | 47.7 | #12 |
| 3 | Claude Mythos 5 | 45.8 | #2 |
| 4 | Claude Mythos Preview | 43.1 | #4 |
| 5 | Claude Opus 4.8 | 40 | #37 |
| 6 | Claude Opus 4.7 | 37.7 | #49 |
| 7 | Gemini 3.1 Pro (Preview) | 37 | #58 |
| 8 | Claude Sonnet 5 | 36.6 | #57 |
| 9 | GPT-5.6 Sol | 35.5 | #19 |
| 10 | Claude Sonnet 4.6 | 35 | #90 |
No result here: #3 Claude Opus 5.5, #6 GPT-6 Astra, #7 GPT-6.1 Sol.
Interactive version: theaggregate.ai/benchmark?slug=proteingym-hard · How It Works · Data refreshed daily, snapshot 2026-10-20.