Protein Design Sequence Generation (Mythos 5.1 System Card): leaderboard
Generate protein sequences satisfying design constraints; scoring combines constraint satisfaction, folding confidence and sequence novelty. No tools. Updated September 2026 benchmark and grader.
Metric: Score (%). Source: www-cdn.anthropic.com. Saturation forecast: Around March 2028. 4 models tracked.
Top models
| # | Model | Score | Overall rank |
|---|---|---|---|
| 1 | Claude Mythos 5.1 | 46 | #2 |
| 2 | Claude Opus 5 | 42.4 | #16 |
| 3 | Claude Mythos 5 | 40.4 | #8 |
| 4 | Claude Sonnet 5 | 20.2 | #65 |
No result here: #3 Claude Opus 5.5, #6 GPT-6 Astra, #7 GPT-6.1 Sol.
Interactive version: theaggregate.ai/benchmark?slug=protein-design-sequence-generation-mythos-5-1-system-card · How It Works · Data refreshed daily, snapshot 2026-11-05.