PROBE Function Prediction — leaderboard
PROBE ontology-based protein function prediction benchmark, reporting F1 across molecular function, biological process, and cellular component targets.
Metric: Average F1. Source: huggingface.co. 24 models tracked.
Top models
| # | Model | Score |
|---|---|---|
| 1 | ESM-1b | 0.84 |
| 2 | ProtXLNet | 0.81 |
| 3 | ProtT5-XL | 0.75 |
| 4 | HMMER | 0.7 |
| 5 | SeqVec | 0.7 |
| 6 | UniRep | 0.69 |
| 7 | ProtBERT-BFD | 0.69 |
| 8 | BLAST | 0.67 |
| 9 | PFAM | 0.67 |
| 10 | MSA-Transformer | 0.67 |
Interactive version: theaggregate.ai/benchmark?slug=probe-function-prediction · How the rankings work · Data refreshed daily, snapshot 2026-07-22.