PROBE Family Classification — leaderboard
PROBE drug-target protein family classification benchmark, reporting MCC across random and sequence-identity split settings.
Metric: Mean MCC. Source: huggingface.co. 21 models tracked.
Top models
| # | Model | Score |
|---|---|---|
| 1 | ProtT5-XL | 0.92 |
| 2 | ProtALBERT | 0.9 |
| 3 | SeqVec | 0.86 |
| 4 | BLAST | 0.86 |
| 5 | PFAM | 0.83 |
| 6 | ProtBERT-BFD | 0.83 |
| 7 | HMMER | 0.81 |
| 8 | ESM-1b | 0.8 |
| 9 | TAPE-BERT-PFAM | 0.77 |
| 10 | ProtXLNet | 0.77 |
Interactive version: theaggregate.ai/benchmark?slug=probe-family-classification · How the rankings work · Data refreshed daily, snapshot 2026-07-22.