PROBE Binding Affinity: leaderboard
PROBE protein-protein binding affinity estimation benchmark, reporting mean squared error for representation methods with available affinity evaluations.
Metric: MSE (lower is better). Source: huggingface.co. 17 models tracked.
Top models
| # | Model | Score | Overall rank |
|---|---|---|---|
| 1 | ProtALBERT | 0.42 | |
| 2 | ProtXLNet | 0.53 | |
| 3 | ProtBERT-BFD | 0.57 | |
| 4 | ProtT5-XL | 0.6 | |
| 5 | HMMER | 0.64 | |
| 6 | SeqVec | 0.65 | |
| 7 | MSA-Transformer | 0.69 | |
| 8 | UniRep | 0.73 | |
| 9 | CPCProt | 0.73 | |
| 10 | BLAST | 0.77 |
Interactive version: theaggregate.ai/benchmark?slug=probe-binding-affinity · How It Works · Data refreshed daily, snapshot 2026-10-20.