PROBE Binding Affinity — leaderboard
PROBE protein-protein binding affinity estimation benchmark, reporting mean squared error for representation methods with available affinity evaluations.
Metric: MSE (lower is better). Source: huggingface.co. 17 models tracked.
Top models
| # | Model | Score |
|---|---|---|
| 1 | ProtALBERT | 0.42 |
| 2 | ProtXLNet | 0.53 |
| 3 | ProtBERT-BFD | 0.57 |
| 4 | ProtT5-XL | 0.6 |
| 5 | HMMER | 0.64 |
| 6 | SeqVec | 0.65 |
| 7 | MSA-Transformer | 0.69 |
| 8 | UniRep | 0.73 |
| 9 | CPCProt | 0.73 |
| 10 | BLAST | 0.77 |
Interactive version: theaggregate.ai/benchmark?slug=probe-binding-affinity · How the rankings work · Data refreshed daily, snapshot 2026-07-22.