PhysDox - End-to-End Diagnosis: leaderboard

PhysDox (2026) tests whether LLMs can audit biomedical physiological-sensing protocols for physical feasibility on a 683-protocol expert-curated Gold set spanning six sensing domains. This board is the end-to-end accuracy (%) on fatal protocols: a protocol counts only if it is first flagged as fatal and then its violated fine-grained constraint is named, under zero-shot prompting; higher is better.

Metric: End-to-end Fine-12 accuracy (%) on the fatal-violation protocols of the 683-protocol expert-curated Gold set of biomedical physiological-sensing protocols (six domains): a protocol counts only if Stage 1 flags it as fatal and Stage 2 names the violated fine-grained constraint; zero-shot prompting, temperature 0.1, JSON output with retries for malformed responses; higher is better. Source: arxiv.org. Saturation forecast: Around February 2027. 6 models tracked.

Top models

#ModelScoreOverall rank
1GPT-5.552.5#49
2DeepSeek V4 Flash49.3#258
3Claude Opus 4.746.7#79
4DeepSeek V4 Pro39.3#188
5MiMo-V2.5-Pro27.6#279
6MiMo-V2.526#354

No result here: #1 Claude Fable 5.2, #2 Gemini 4 Carbon, #5 Claude Opus 5.5.

Interactive version: theaggregate.ai/benchmark?slug=physdox-end-to-end-diagnosis · How It Works · Data refreshed daily, snapshot 2026-11-13.