PFArena - Anchor-Informed Multi-Mutant Ranking: leaderboard
Task T3 of AMix-Bio's PFArena protein-mutation benchmark (September 2026): given one experimentally measured anchor mutant and its score, rank candidate successors that add further mutations to it. Ground truth is deep mutational scanning data. Spearman correlation between the model's ranking and the measured scores (Random 0.04); higher is better. Prompted LLMs only.
Metric: Spearman. Source: huggingface.co. Saturation forecast: Around November 2027. 9 models tracked.
Top models
| # | Model | Score | Overall rank |
|---|---|---|---|
| 1 | Gemini 4 Argon | 0.38 | #11 |
| 2 | Claude Opus 5 | 0.35 | #20 |
| 3 | GPT-6 Astra | 0.35 | #6 |
| 4 | GPT-6.1 Sol | 0.33 | #10 |
| 5 | Kimi K3 | 0.31 | #53 |
| 6 | Gemini 3.1 Pro (Preview) | 0.29 | #91 |
| 7 | GLM-5.2 | 0.27 | #137 |
| 8 | DeepSeek V4 Pro | 0.26 | #181 |
| 9 | DeepSeek V4.1 Flash | 0.26 | #58 |
No result here: #1 Claude Fable 5.2, #2 Gemini 4 Carbon, #5 Claude Opus 5.5.
Interactive version: theaggregate.ai/benchmark?slug=pfarena-anchor-informed-multi-mutant-ranking · How It Works · Data refreshed daily, snapshot 2026-11-12.