Organic Chemistry V2 (Mythos 5.1 System Card): leaderboard
Organic chemistry tasks involving spectroscopy, molecular structures, multi-step synthesis and reaction prediction. V2 adds expert-recommended harder problems; September 2026 scores reflect expert feedback.
Metric: Score (%). Source: www-cdn.anthropic.com. Saturation forecast: Around May 2027. 6 models tracked.
Top models
| # | Model | Score | Overall rank |
|---|---|---|---|
| 1 | Claude Mythos 5.1 | 69.2 | #2 |
| 2 | Claude Opus 5 | 65.7 | #16 |
| 3 | Claude Mythos 5 | 64.3 | #8 |
| 4 | Gemini 3.1 Pro (Preview) | 45.9 | #64 |
| 5 | Claude Sonnet 5 | 43.7 | #65 |
| 6 | GPT-5.6 Sol | 43.2 | #22 |
No result here: #3 Claude Opus 5.5, #6 GPT-6 Astra, #7 GPT-6.1 Sol.
Interactive version: theaggregate.ai/benchmark?slug=organic-chemistry-v2-mythos-5-1-system-card · How It Works · Data refreshed daily, snapshot 2026-11-05.