OpenAI GPT-5.6 System Card - Hard Negative Protein Binding Prediction: leaderboard
Biosecurity capability slice from OpenAI's GPT-5.6 system card — hard-negative protein-binding prediction; OpenAI-run frontier comparison.
Metric: pass@4 (%). Source: deploymentsafety.openai.com. Saturation forecast: Around 2031. 4 models tracked.
Top models
| # | Model | Score | Overall rank |
|---|---|---|---|
| 1 | GPT-5.6 Sol | 7.6 | #19 |
| 2 | GPT-5.4 (Thinking) | 3.5 | #79 (GPT-5.4) |
| 3 | GPT-5.5 | 1.5 | #31 |
| 4 | GPT-5.5 Pro | 0 | #17 |
No result here: #3 Claude Opus 5.5, #6 GPT-6 Astra, #7 GPT-6.1 Sol.
Interactive version: theaggregate.ai/benchmark?slug=openai-gpt-5-6-system-card-hard-negative-protein-binding-prediction · How It Works · Data refreshed daily, snapshot 2026-10-20.