OpenAI GPT-5.6 System Card - DNA Sequence Design for TF Binding: leaderboard
Biosecurity capability slice from OpenAI's GPT-5.6 system card — designing DNA sequences for transcription-factor binding; OpenAI-run frontier comparison.
Metric: pass@1 (%). Source: deploymentsafety.openai.com. Saturation forecast: Around 2029. 4 models tracked.
Top models
| # | Model | Score | Overall rank |
|---|---|---|---|
| 1 | GPT-5.5 Pro | 16.5 | #17 |
| 2 | GPT-5.5 | 13.82 | #31 |
| 3 | GPT-5.6 Sol | 13.7 | #19 |
| 4 | GPT-5.4 (Thinking) | 12.82 | #79 (GPT-5.4) |
No result here: #3 Claude Opus 5.5, #6 GPT-6 Astra, #7 GPT-6.1 Sol.
Interactive version: theaggregate.ai/benchmark?slug=openai-gpt-5-6-system-card-dna-sequence-design-for-tf-binding · How It Works · Data refreshed daily, snapshot 2026-10-20.