Nucleotide Transformer Benchmark — leaderboard
Genomics foundation-model leaderboard evaluating nucleotide transformers on downstream DNA tasks such as histone marks, regulatory elements, and RNA-production prediction.
Metric: Mean MCC. Source: huggingface.co. 16 models tracked.
Top models
| # | Model | Score |
|---|---|---|
| 1 | NT-Multispecies-v2 (250M) | 0.66 |
| 2 | NT-Multispecies-v2 (500M) | 0.66 |
| 3 | NT-Multispecies (2.5B) | 0.66 |
| 4 | NT-Multispecies-v2 (100M) | 0.65 |
| 5 | NT-1000G (2.5B) | 0.65 |
| 6 | NT-Multispecies-v2 (50M) | 0.64 |
| 7 | NT-HumanRef (500M) | 0.63 |
| 8 | DNABERT-2 | 0.63 |
| 9 | NT-1000G (500M) | 0.63 |
| 10 | Enformer | 0.63 |
Interactive version: theaggregate.ai/benchmark?slug=nucleotide-transformer-benchmark · How the rankings work · Data refreshed daily, snapshot 2026-07-22.