Apodex Discovery - AAV Tropism Prediction: leaderboard
Apodex Discovery (2026) puts agentic solvers in a domain-specific environment for adeno-associated virus capsid design with real screening data and hidden verifiers. This task asks the solver to predict the tissue enrichment of AAV9 peptide-insertion variants across organs, species and human assays, scored by correlation with the measured enrichment (-1 to 1); higher is better.
Metric: Correlation (-1 to 1) between predicted and measured tissue enrichment of AAV9 peptide-insertion variants (Fit4Function screens), averaged over multi-organ mouse, cross-species macaque and human in-vitro instances; solver runs in the authors' domain-specific environment. Source: arxiv.org. Saturation forecast: Around February 2027. 10 models tracked.
Top models
| # | Model | Score | Overall rank |
|---|---|---|---|
| 1 | Claude Opus 5 | 0.65 | #20 |
| 2 | Kimi K3 | 0.65 | #53 |
| 3 | GLM-5.2 | 0.64 | #137 |
| 4 | Claude Opus 4.8 | 0.64 | #56 |
| 5 | Apodex 1.1 | 0.64 | #282 |
| 6 | Claude Sonnet 4.6 | 0.63 | #158 |
| 7 | DeepSeek V4 Pro | 0.61 | #181 |
| 8 | Qwen 3.5 397B A17B | 0.61 | #242 |
| 9 | GPT-5.5 | 0.6 | #48 |
No result here: #1 Claude Fable 5.2, #2 Gemini 4 Carbon, #5 Claude Opus 5.5.
Interactive version: theaggregate.ai/benchmark?slug=apodex-discovery-aav-tropism-prediction · How It Works · Data refreshed daily, snapshot 2026-11-12.